| Customization: | Available |
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| Application: | Internal Medicine |
| Usage Mode: | For external use |
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Properties
This product is a colorless and clear liquid; the taste is slightly salty.
Pharmacology and Toxicology
Sodium and chlorine are important electrolytes in the body, mainly in the extracellular fluid, and play a very important role in maintaining the body's normal blood and extracellular fluid volume and osmotic pressure. The normal serum sodium concentration is 135~145m mol/L, accounting for 92% of plasma cations and 90% of the total osmotic pressure. Therefore, the amount of plasma sodium plays a decisive role in osmotic pressure. The normal serum chlorine concentration is 98~106m mol/L. The human body is mainly regulated by the hypothalamus, posterior pituitary gland and kidney to maintain the stability of body fluid volume and osmotic pressure.
Pharmacokinetics
In the gastrointestinal tract, sodium is almost completely absorbed through the active transport of intestinal mucosal cells. Sodium is mainly excreted by the kidneys.
Indications
1. Water loss caused by various reasons, including hypotonicity, isotonicity and hypertonicity.
2. In hypertonic nonketotic coma, the application of isotonic or hypotonic sodium chloride can correct dehydration and hypertonic state.
3. Low-chlorine metabolic alkalosis.
4. Externally use normal saline to flush eyes and wash wounds.
5. Water bladder for obstetrics to induce labor.
Dosage
1. Hypertonic water loss: The osmotic concentration of brain cells and cerebrospinal fluid increases in patients with hypertonic water loss. If the sodium concentration and osmotic concentration of plasma and extracellular fluid drop too quickly, brain edema may be caused. Therefore, it is generally believed that within 48 hours of the beginning of treatment, plasma sodium concentration does not drop more than 0.5 mmol/L per hour. If the patient has shock, sodium chloride injection should be given first, and the colloid should be supplemented as appropriate. After the shock is corrected, serum sodium>155mmol/L, plasma osmotic concentration>350mOSm/L, 0.6% hypotonic sodium chloride injection can be given. When the plasma osmotic concentration is <330mO5m/L, switch to 0.9% sodium chloride injection. The total amount of fluid replacement is calculated according to the following formula as a reference:
Generally, half of the amount will be replenished on the first day, and the remaining amount will be replenished in the next 2 to 3 days, and adjusted according to the cardiopulmonary and kidney function.
2. Isotonic water loss: In principle, give isotonic solutions, such as 0.9% sodium chloride injection or compound sodium chloride injection, but the chlorine concentration of the above solution is significantly higher than that of plasma, and large amounts of use alone can cause hyperchloremia. Therefore, 0.9% sodium chloride injection and 1.25% sodium bicarbonate or 1.86% (1/6 M) sodium lactate can be prepared at a ratio of 7:3 and then refilled. The latter has a chlorine concentration of 107mmol/L and can correct metabolic acidosis. The amount of replenishment can be calculated based on body weight or hematocrit as a reference. Calculated by body weight: fluid supplement (L)=(weight loss (kg)×142)/154; calculated by hematocrit:
The amount of fluid replacement (L) = (actual hematocrit-normal hematocrit) × body weight (Kg) × 0.2/normal hematocrit. Normal red blood cell pressure
It is 48% for males and 42% for females.
3. Hypotonic water loss: In severe hypotonic water loss, the solute in brain cells is reduced to maintain cell volume. If the treatment causes the plasma and extracellular fluid sodium concentration and osmotic concentration to rise rapidly, it can cause brain cell damage. It is generally believed that when blood sodium is lower than 120mmol/L, the rate of increase in blood sodium will be 0.5mmol/L per hour and not more than 1.5mmol/L per hour.
When the blood sodium is lower than 120mmol/L or symptoms of the central nervous system occur, 3%~5% sodium chloride injection can be instilled slowly, and it is generally required to increase the blood sodium concentration to more than 120mmol/L within 6 hours. Sodium supplementation (mmol) = [142-actual blood sodium concentration (mmol/L)] × body weight (Kg) × 0.2. When the blood sodium rises to above 120~125mmol/L, you can switch to isotonic solution or isotonic solution and add hypertonic glucose injection or 10% sodium chloride injection as appropriate.
4. Low-chlorine alkalosis: give 0.9% sodium chloride injection or compound sodium chloride injection (ringer's solution) 500~1000ml, and decide the dosage according to the situation of alkalosis.
5. External use: Wash the wound with physiological sodium chloride solution and rinse the eyes.
Adverse reactions
1. Too much or too fast infusion can cause water and sodium retention, causing edema, increased blood pressure, increased heart rate, chest tightness, dyspnea, and even acute left heart failure.
2. Too much or too fast hypotonic sodium chloride can cause hemolysis and cerebral edema.
Precautions
1. Use with caution in the following situations:
(1) Edema diseases, such as nephrotic syndrome, liver cirrhosis, ascites, congestive heart failure, acute left heart failure, cerebral edema and idiopathic edema, etc.;
(2) Patients in the oliguria stage of acute renal failure and chronic renal failure with reduced urine output and poor response to diuretics;
(3) Hypertension;
(4) Hypokalemia.
2. According to clinical needs, check the serum sodium, potassium, chloride ion concentration; blood acid-base concentration balance index, kidney function, blood pressure and heart and lung function.
Children's Medication
The amount and speed of rehydration should be strictly controlled
Medication for elderly patients
The amount and speed of rehydration should be strictly controlled
medicine interactions
1. When used as a drug solvent or diluent, the compatibility of drugs should be noted;
2. It can cause hypernatremia and hypokalemia, and can cause loss of bicarbonate.
| Comercial Packing | 10x10's/Box or Customized |
| Production Time | About 30-60days after artwork confirmed |
Since 2015, NINGBO VOICE BIOCHEMIC CO. LTD. is a professional company to offer one-package service for FPP (Finished Pharmaceutical Products ); APIs (Active Pharmaceutical Ingredients); Chemicals (Pharmaceutical Intermediates ); Veterinary Pharmaceuticals.that meet requirements of Standard GMP and current BP,USP version.
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