GMP Medicine Large Volume Infusions 0.2g/100ml Ciprofloxacin Lactate

• Application: Antibiotics
• Usage Mode: For oral administration
• Suitable for: Elderly, Children, Adult
• State: Solid
• Shape: Tablet
• Type: Organic Chemicals
• Pharmaceutical Technology: Chemical Synthesis
• Certification: GMP Bp/USP
• Shelf Life: 3 Years
• Transport Package: Carton
• Specification: 100′s/Box
• Trademark: Ningbo Sinofin
• Origin: China
• HS Code: 3004201700
• Production Capacity: 10000000

Product Description

Generic name: Ciprofloxacin Lactate and Sodium Chloride Injection

English name: Ciprofloxacin Lactate Injection

Chinese Pinyin: Rusuan Huanbingshaxing Zhusheye

The main component of this product is: ciprofloxacin lactate, its chemical name is: 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3 -Quinoline carboxylic acid lactate.

Molecular formula: C17 H18FN3O3·C3H6O3

Molecular weight: 421.43

[Properties] This product is a colorless or almost colorless clear liquid.

Pharmacology and Toxicology

Pharmacological action: This product has a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic gram-negative bacilli. It has a good antibacterial effect in vitro against the following bacteria: most bacteria of the Enterobacteriaceae, including Citrobacter spp. , Enterobacter aerogenes, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. It also has antibacterial activity against multi-drug resistant bacteria. The penicillin-resistant Neisseria gonorrhoeae, the enzyme-producing influenza Bacillus and Moraxella all have high antibacterial activity. It has antibacterial effect on most strains of Pseudomonas such as Pseudomonas aeruginosa. This product has antibacterial activity against methicillin-sensitive Staphylococcus, and only moderate antibacterial activity against Streptococcus pneumoniae, Streptococcus hemolyticus and Enterococcus faecalis. It has a good antimicrobial effect on Chlamydia trachomatis, Mycoplasma, Legionella, and has antibacterial activity on Mycobacterium tuberculosis and atypical mycobacteria. Poor antibacterial activity against anaerobic bacteria.

Ciprofloxacin is a bactericide, which inhibits DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase, leading to bacterial death.

Toxicological research:

Carcinogenicity and mutagenicity: 8 in vitro mutagenicity tests were performed on ciprofloxacin, and 2 of them were positive (rat hepatocyte DNA repair test and mouse lymphoma cell reversion test). However, in vivo tests of rat hepatocyte DNA repair test, micronucleus test (mice), and dominant test (mice) were all negative. Long-term carcinogenicity in vivo tests on rats and mice have been completed. After daily oral medication for 2 years, these animals did not show any carcinogenic or tumorigenic effects of ciprofloxacin.

Reproductive toxicity: Rats and mice were used to take 6 times the usual daily dose of humans for reproductive research. Ciprofloxacin has not been found to be harmful to the fetus or cause fertility damage. When ciprofloxacin is used in rabbits (30 and 100 mg/kg orally), gastrointestinal disturbances occur, leading to weight loss and increased miscarriage in female rabbits. However, no teratogenic effects were observed at the two doses. After intravenous administration of up to 20mg/kg, there was no maternal toxicity, embryo toxicity or teratogenicity. However, there are not enough, well-controlled studies on pregnant women. For pregnant women, ciprofloxacin can only be used when its potential benefits outweigh the potential risks to the fetus.

[Pharmacokinetics] After intravenous infusion of 200mg and 400mg of this product within 60 minutes, the blood drug depth peak is about 1 hour, respectively 2.1mg/L and 4.6mg/L. It can be widely distributed in various body fluids (including cerebrospinal fluid) and tissues, and the concentration in the tissues often exceeds the blood concentration. The protein binding rate is about 20%-40%. After intravenous administration, 50-70% of the drug is excreted in the urine in its original form, and about 14% is excreted in bile and feces. More than 90% of the dose is discharged within 24 hours. The elimination half-life is 5-6 hours, which can be prolonged by decreased renal function.

[Indications] Used for sensitive bacteria:

1. Urogenital system infections, including simple, complicated urinary tract infections, bacterial prostatitis, Neisseria gonorrhoeae urethritis or uterine

Cervical inflammation (including those caused by enzyme-producing strains).

2. Respiratory tract infections, including acute onset of bronchial infections and lung infections caused by sensitive gram-negative bacilli.

3. Gastrointestinal infections are caused by Shigella, Salmonella, Enterotoxigenic Escherichia coli, Hydrophilic Aeromonas, and Vibrio parahaemolyticus.

4. Typhoid fever.

5. Bone and joint infections.

6. Skin and soft tissue infections.

7. Systemic infections such as sepsis.

[Usage and Dosage] This product is for intravenous drip administration. For any patient, the dosage should be determined according to the degree and nature of the infection, the sensitivity of pathogenic bacteria, the patient's body resistance and liver and kidney function.

The general dosage for adults is 0.1-0.2g once, intravenously instilled once every 12 hours, and the infusion time of every 0.2g should be at least 30 minutes. For severe infection or Pseudomonas aeruginosa infection, the dose can be increased to 0.4g once a day 2-3 times.

The course of treatment depends on the degree of infection. Usually simple lower urinary tract infections are 5-7 days; complicated urinary tract infections are 7-14 days; pneumonia and skin and soft tissue infections: 7-14 days; intestinal infections: 5-7 days; bone and joint infections: 4-6 Weeks or longer; typhoid fever: 10-14 days.

Adverse reactions

1. Gastrointestinal reactions are more common and can be manifested as abdominal discomfort or pain, diarrhea, nausea or vomiting, indigestion, and anorexia. If you find severe long-term diarrhea during treatment, you must consult a doctor, because this may be a serious gastrointestinal disease, pseudomembranous enteritis. Once this happens, the drug should be stopped immediately. Give appropriate treatment (such as giving vancomycin). Drugs that inhibit gastrointestinal motility are prohibited.

2. Central nervous system reactions may include dizziness, headache, drowsiness or insomnia. A few cases may have abnormal peripheral pain, increased intracranial pressure, ataxia, convulsions, anxiety, confusion, depression, hallucinations, seizures, etc. Individual patients even have mental reaction and self-risk behavior. Some patients may have these reactions at the first time, so they should stop the medication immediately and notify the doctor.

3. Allergic reactions: skin rash, skin itching, drug fever, urticaria, and occasionally exudative erythema multiforme and angioedema may occur. In some cases, laryngeal edema, dyspnea, and anaphylactic shock may occur at the first medication, and anti-shock treatment should be given immediately. A few patients have photosensitivity.

4. Occasionally:

(1) Abnormal vision, impaired taste, tinnitus, and hearing loss.

(2) Hematuria, interstitial nephritis, hepatitis, and liver necrosis failure.

(3) Phlebitis or thrombophlebitis.

(4) Crystal urine is more common in high-dose applications.

(5) Joint pain, muscle pain, tenosynovitis, Achilles tendinitis;

(6) Tachycardia, facial flushing, migraine, syncope;

(7) Blood system effects: anemia, thrombocytopenia, leukopenia, eosinophilia, hemolytic anemia, coagulation changes. (8) Skin spotting (petechia) blisters, accompanied by bleeding (blood blisters) and crusted nodules (papules), stevens-Johnson and Yell syndrome.

(9) Long-term and repeated application of this product can cause infection by resistant bacteria or yeast-like bacteria.

5. Abnormal laboratory data: a small number of patients may have elevated serum aminotransferase, alkaline phosphatase, cholestatic jaundice, especially in patients with liver damage, blood urea nitrogen, creatinine or bilirubin increased, and individual patients have hyperglycemia and crystals Urine, hematuria.

6. Ciprofloxacin can affect the patient's ability to drive or operate machinery, especially in patients who drink at the same time.

[Contraindications] Patients who have a history of allergies to this product and any fluoroquinolones are contraindicated.

Our company is a pharmaceutical company which is specialized in production, R&D, export of medicines. our products covering API, Intermediates, and Pharmaceutical Formulations for human and veterinary using
Besides the much experience in the international transaction we have a professional documentation team for the registration indifferent countries, already registered more than 1oo kinds of pharmaceutical medicines in many countries around the world and the products have been exported to North America, South America, India and Pakistan, Southeast Asia and so on.

    

Manufacturing is carried out according to the strict GMP rules and regulations, all the production workshops have passed the national GMP certification and some were internationally certified, frequently internal and third party inspections were conducted to guarantee that all of our products meet the standards required by our clients.

 

. OEM/ODM service
. Free professional and creative artwork design.
. Registration documents (CTD/ACTD) supported
. GMP Certificate
. Manufacturing Licence
. COPP(Certificate of Pharmaceutical Product)
. FSC( Free Sale Certificate)
. CCPIT certification
. Embassy Notarization
. Other documents based on request.

Q1: How to order?
1)Contact us about what you need and your quantity, we will send you the contract.
2)Complete the payment.
3)We will arrange to the shipment.
4)B/L number will be informed to you.
5)Goods delivered

Q2: Can i get samples?
A: Yes, we can supply the free sample for API, but the shipping cost be paid by our customers.

Q3: How to confirm the Product quality before place orders?
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
 

ANTIBIOTIC & ANTI-VIRUS	USP or BP Standard
PRODUCT	SPECIFICATION	NORMAL  PACKING
1.Amikacin	Injection  0.5g/2Ml	10vials/Box
2.Amoxycillin	Powder Inj  0.25g 0.5g.	50vials/Box
	Capsule  0.25g,0.5g	10'sx10/Box
	For Syrup 250mg/5Ml	60ml/Vial
3.Amoxycillin + Clavulanate K   (Co-amoxiClav)	Powder In. 600mg 1.2g (5+1)	10vials/Box
	Tablet 375mg (2+1)	6tabls/Box
	Dry Syrup 375mg  (2+1)  60ml	1's/Box
4.Ampicillin	Powder Inj 0.25g  0.5g  1.0g	50vials/Box
	For Syrup  250mg/5Ml	60ml/Vial
5.  Azithromycin	Tablet 0.25g,0.5g	10's/Blister
6.  Aztreonam	For Injection  0.5g	10Vial/Box
7.Cefazolin Sodium	Powder Injection  0.5g	50vials/Box
8.Cefotaxime  Sodium	Powder Inj.  1g	10vials/Box
9.Cefoperazone Sodium	Powder inj. 0.5g  1g	1vial/Box
10.Ceftazidine	Powder Inj. 1g	1vial/Box
11.Ceftriaxone Sodium	Powder Inj  1g	1vial/Box
12.Cefuroxime Sodium	Powder Inj.  750mg	10vials/Box
13.Chloramphenicol	Capsule  250mg	1000's/Tin
	Succinate Injection 1g	50vials/Box
14.Ciprofloxacin Hcl	Tablet  0.5g  0.25g	10'sx10blister/Box
	Infusion   100ml	Bottle
15.Doxycycline	Capsule  100mg	10'sx100blister/Box
	Tablet  250mg	10's/Blister
16.Gentamicin	Injection  80mg/2ml	100's/Box
	Eye & Ear Drop 0.4% 10ml	10pieces/Box
17.Lincomycin	Injection  600mg/2ml	5amps/Box
	Capsule 500mg	12'sx2blister/Box
18.Meropenem	Powder inj. 500mg; 1G	1's/Box
19.Crystal Penicillin Sodium	Powder Inj.1mega  5mega	50vials/Box
20.Procainpenicillin Fortified	Powder Inj. 0.4mega ; 4mega	50vials/Box
21.Streptomycin	Powder Inj 1.0g ; 5.0g	50vials/Box
22.Tetracycline	Capsule  250mg	1000's/Tin
	Eye Onitment 0.1% 4g	1tube/Box
Biochemical pharmaceutics	SPECIFICATION	NORMAL  PACKING
1.Antirabies Serum	Inj.400iu/2ml ; 1000iu/5ml	5'S/Box
2.Chymotrypsin Inj.	5000I.U./5Vial+5Amps solent	5+5/Box
3.Glutathion	Powder for Inj.  600mg	10's/Box
4.Human Gamma Immunoglobulin	(5%)  50ml  IV	1'S/Box
5.In-sulin Inj.	300iu/3ml	1's/Box
6. Polygeline	3.5%  500ml , IV	1's/Box
7.Tetanus Antitoxin	1500iu,10000iu	10's/Box
Antimalaria & Antimicrotic	SPECIFICATION	NORMAL  PACKING
1.Artemether	Injection  80mg/Ml	6amps/Box
2.Artemether +lumifrantrine	Tablet 20mg+120mg	24'S/Box
	Solft Capsule 80+480mg	6's/Box
3.Dihydroartemisine+Piperaquine	Tablet 40+320MG	9'S/Box
	Dry suspension 90+720MG	60ml/Box
4.Chloroquine Phosphate	Tablet  250mg	1000's/Tin
	Injection  64.5mg/Ml  5ml	100amps/Box
5.Clotrimazole	Cream 1% 20g/Tube	1tube/Box
6. Ketoconazole complex	Cream 1% 15g	1'S/Tube/Box
7. Metronidazole	Inj  5% 100ml	1bottle/Box (Hanger)
	Tablet  0.2g  0.25g  0.4g	1000's/Tin
8.Miconazole Nitrate	Cream 20mg/g 5g	1'S/Box
9. Nystatin	Cream 0.1mega/g 15g	1'S/Box
	Oral suspension 100,000IU/ml, 30ml	1's/Box
10.Quinine 2HCL	Inj. 600mg/2ml	10'sx10tray/Box
11.Terbinafine HCL	Cream 1% , 10g/tube	1Tube/Box
Digestive System  & Cardiovascular	SPECIFICATION	NORMAL  PACKING
1.Cimitidine	Tab. 0.2g 0.4g	1000'S/Tin
	Injection 200mg/2ml	100'S/Box
2.Hyoscine Butylbromide	Inj 20mg/Ml	10'sx10tray/Box
3.Lansoprazole	Capsule 30mg	2x12/Blister/Box
4.Metoclopramide	Injection 10mg/Ml	100amps/Box
5.Omeprazole	Tablet  20mg	2x12's/Blister/Box
	For Injection 40mg	10Vials/Box
6.Pantoprazole	Capsule, Tablet 40mg	2x10's/Box
7.Amlodipine Besylate	Tablet 5mg ; 10mg	10'sx10tray/Box
8.Atorvastatin	Tablet 10mg, 20mg	10x10's/Box
9.Fursemide	Inj.  20mg/2ml	10'sx10tray/Box
10. Irbesartan	Tablet 150mg	10 x 10's/Box
11.Lovastatin	Tablet 40mg	12'sx1blister/Box
12.Nitroglycerine	Aerosol  14g 200dose	1vial/Box
13.Simvastatin	Film-coate Tab. 10mg; 20mg	10x10's/Box
14.Tirofiban	Injection  12.5mg/50ml	1's/Box
15. Valsantan	Tablet     80mg	10x10's/Box
Anticarcinogen (oncology) & Anti-HIV	SPECIFICATION	NORMAL  PACKING
1.Bicalutamide	Capsule 50mg	3x10'S/Box
2.Calcium Folinate	Injection 100mg.	10'S/Box
3.Docetaxel	Injection 20mg/0.5ml	1's+1/Box
4.Doxorubicin	Powder Inj. 50mg	10's/Box
5.Epirubicin	Powder Inj. 50mg	10's/Box
6.Gefitinib	Tablet 0.25mg	10's/Box
7.Lamivudine (3TC)	Capsule 100mg	10's/Box
8.Lomustine	Capsule  100mg	6'S/Blister/Box
9.Methotrexate (Lyophilized)	Inj  5mg 10mg	100vials/Box
	Tablet 25mg	100tablets/Box
10.Paclitaxel	Injection30mg/5ml,60mg/10ml	1's/Box
11.Granisetron Hydrochloride	Injection 1mg/1ml, 3mg/3ml	1'S/Box
12.Zidovudine (ZDO,AZT)	Tablet 300mg	60's/Box
13.Zoledronic Acid	Powder  for Inj. 4mg,	1's/Box
14.Tropisetron	Injection 5.64mg/5ml	1's/Box
Vitamin & Nurtures	SPECIFICATION	NORMAL  PACKING
1.Calcium Gluconate	Inj. 10% 10ml	50amps/Box
2.FeSO4 + Folic Acid	Tab.(200mg+1mg)	1000'S/Tin
3.Neurozin (Vitamin Complex)	Syrup 240ml	1's/Bottle
4.Vitamin A+D	Soft Capsule 10,000+3,000iu	500'S/Tin
5.Vitamin B1	Injection  100mg/Ml	10'sx10tray/Box
6.Vitamin B Complex	Injection (B12+B1+B6)  2ml	10's/Box
	(B1+B2+B6) 10ml	50Vials/Box
7.Vitamin B6	Inj. 100mg/Ml	10'sx10tray/Box
8.Vitamin B12	Inj.  1mg/2ml  0.5mg/Ml	100amps/Box
9.Vitamin C	Inj. 500mg/5ml	100amps/Box
	Tablet 1g	10's/Tin
10.Vitamin D3	Inj. 600mg/Ml	10's/Box
11.Vitamin K1	Inj.  10mg/Ml	10's/Box
12.Vitamin K3	Inj.  10mg/Ml	10's/Box
Analgesic&Antipyretic	SPECIFICATION	NORMAL  PACKING
1.Aspirin	Tablet 0.3g, 0.5g	100's/Box
2.Ibuprofen	Tablets 0.2g, 0.4g, 0.6g, 0.8g	100's/Box
	Syrup 100mg/5ml 25ml	1's/Box
3.Indomethacin	Capsules 25mg	1000's/Box
4.Piroxicam	Capsule 20mg	1000's/Box
5.Hydroxychloroquine	Tablet 0.1g,0.2g	1000's/Box
6.Ibuprofen + paracetamol	Capsule	1000's/Box
7.Diclofenac sodium and paracetamol	Tablets 50mg + 500mg	1000's/Box
8.Diclofenac sodium	Tablet 0.2g 0.4g	1000's/Tin
	Injection 75mg / 3ml	100Amps / Box
9.Paracetamol	Tablet 0.5g 0.3g	1000's/Box
	Injection 300mg/2ml	10ampoules/Box
	Infusion 1g/100ml	1's/Bottle
10.Leflunomide	Tablet 5mg 10mg 20mg	100's/Box
11.Mesalazine	Tablet 0.5g	100's/Box
Hormone & Endocrine	SPECIFICATION	NORMAL  PACKING
1.Dexamethason  Phosphate	Inj. 4mg/Ml	5x5amps/Tray/Box
2.Pred-nisolone	Tablet   5mg	1000's/Tin
3.Methylpred-nisolone	Tablet   4mg	1000's/Tin
	Inj. 40mg 500mg	10's/Box
4.Hydro-cortisone Sodium Succinate	Powder Injection 100mg	50vials/Box
5.Levonorgestrol	Tablet  0.75mg	10's x10/Box
6.Levonorgestrel +Ethinylestradiol	Tablet 0.15mg+0.03mg	21's/Blister
7.Progesterone	Oil Inj. 20mg/Ml ,25mg/Ml	100amps/Box
8.Tes-tosterone Proplonate	Oil Inj.10mg/Ml  25mg/Ml	10'sx10tray/Box
9.Tri-amcinolone acetonide	Inj. 80mg/2ml	10's/Box
10.Metformin	Tablet 0.25g 0.5g	10's x10/Box
Other	SPECIFICATION	NORMAL  PACKING
1.Adrenine	Injection 1mg/Ml	10's/Box
2.Atracurium Besylate	Powder for inj. 25mg/2.5ml; 50mg/5ml	1's/Box
3.Atropine	Inj. 1mg/Ml	10'sx10tray/Box
4.Chlopromazine Hcl	Injection 25mg/2ml	100'S/Box
5.Dia-zepam Inj.	Inj. 20mg/2Ml	10's/Box
6.Promethazine	Inj. 25mg/2ml	10'sx10tray/Box
7.Ambroxol HCL	syrup 30mg/5ml  100mL	1Bottle/Box
8.Aminophilline	Injection 0.25g 10ml	50's/Box
9. Salbu-tamol	Aerosol 100mcg/Dose 200Doses	1bottle/Box
10. Beclomethasone Dipropionate	Aerosol  100mcg 200doses	1's/Box
11.Xylometazoline	Nasal drop   0.1% 10Ml	Plastic Vial
12. Diosmin	Tablet 500mg	10'sx10/Box
13.Metformini Hcl	Tablet 0.25g	1000's/Tin
14.Orlistat	Tablet  120mg	10x10's/Box
15.Vecuronium Bromide	Powder for Injection 4mg	1Vial/Box